Download or read book Optimization and Design of Robust Supply Chain Networks written by Ram Prashanth Radha Krishnan and published by . This book was released on 2015 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: A robust and cost effective distribution network is critical to any fast growing company, both to meet demand under normal conditions and to adapt to temporary facility distributions. This paper develops two mixed integer programming models to optimize the supply chain of a national medical consumable supplies company with international manufacturers or otherwise geographically remote from demand locations and consistent monthly repeating demand and to provide some robustness against temporary disruption of facility operations. Specifically, p-median single-echelon and hub-and-spoke multi-echelon models are used to determine optimal locations of warehouses and distribution facilities that minimize total transportation cost, with a potential savings in the motivating application of 13% (approximately $1.4 million annually). Sensitivity analyses to a range of scenarios, furthermore, suggest that the optimal distribution network is affected primarily by manufacturer locations rather than customer locations within United States.