Download or read book Nuclear Receptor-mediated Transcriptional Regulation in Prostate Cancer Cells written by and published by . This book was released on 2014 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related death for men in the United States. In prostate carcinogenesis, the critical role of androgen receptor (AR) signaling has been well established and the transcriptional networks governed by AR have been under rigorous investigations. AR belongs to nuclear receptor (NR) superfamily which, by directly regulating gene expression in response to hormones, plays important roles in normal development and pathological processes. In addition to AR, other NRs, such as vitamin D receptor (VDR) and retinoic acid receptor alpha (RARA), have also been shown to affect prostate cancer development. However, the understanding of transcriptional programs governed by these NRs is fragmentary and how they interact with AR is poorly understood. In order to address these questions, we have used an integrated genomic approach to uncover the transcriptional networks governed by AR, VDR and RARA in the prostate cancer cell line LNCaP.