Mechanistic and Synthetic Studies of Asymmetric Reactions Catalyzed by Cinchona Alkaloids
Author | : Jun Song |
Publisher | : |
Total Pages | : 277 |
Release | : 2007 |
ISBN-10 | : 1109959494 |
ISBN-13 | : 9781109959499 |
Rating | : 4/5 (94 Downloads) |
Download or read book Mechanistic and Synthetic Studies of Asymmetric Reactions Catalyzed by Cinchona Alkaloids written by Jun Song and published by . This book was released on 2007 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: We discovered a highly enantioselective Mannich reaction of 1,3-dicarbonyl compounds to N-Boc protected aryl and alkyl imines by using cinchona alkaloid derivatives bearing thiourea functionalities at C9 position. Products of the Mannich reaction are readily transformed into beta-amino acids or beta-amino ketones.