Iron-Sulfur Clusters in Chemistry and Biology

Iron-Sulfur Clusters in Chemistry and Biology
Author :
Publisher : Walter de Gruyter GmbH & Co KG
Total Pages : 672
Release :
ISBN-10 : 9783110308426
ISBN-13 : 3110308428
Rating : 4/5 (26 Downloads)

Book Synopsis Iron-Sulfur Clusters in Chemistry and Biology by : Tracey Rouault

Download or read book Iron-Sulfur Clusters in Chemistry and Biology written by Tracey Rouault and published by Walter de Gruyter GmbH & Co KG. This book was released on 2014-08-20 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960s to elucidation of the roles of iron sulfur clusters as prosthetic groups of enzymes, such as the citric acid cycle enzyme, aconitase, and numerous other proteins, ranging from nitrogenase to DNA repair proteins. The capacity of iron sulfur clusters to accept and delocalize single electrons is explained by basic chemical principles, which illustrate why iron sulfur proteins are uniquely suitable for electron transport and other activities. Techniques used for detection and stabilization of iron-sulfur clusters, including EPR and Mossbauer spectroscopies, are discussed because they are important for characterizing unrecognized and elusive iron sulfur proteins. Recent insights into how nitrogenase works have arisen from multiple advances, described here, including studies of high-resolution crystal structures. Numerous chapters discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.


Iron-Sulfur Clusters in Chemistry and Biology Related Books

Iron-Sulfur Clusters in Chemistry and Biology
Language: en
Pages: 672
Authors: Tracey Rouault
Categories: Science
Type: BOOK - Published: 2014-08-20 - Publisher: Walter de Gruyter GmbH & Co KG

DOWNLOAD EBOOK

This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960s to elucidation of the roles of ir
Biological Inorganic Chemistry
Language: en
Pages: 794
Authors: Ivano Bertini
Categories: Science
Type: BOOK - Published: 2007 - Publisher: University Science Books

DOWNLOAD EBOOK

Part A.: Overviews of biological inorganic chemistry : 1. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability
Fe-S Proteins
Language: en
Pages: 351
Authors: Patricia C. dos Santos
Categories: Proteins
Type: BOOK - Published: 2021 - Publisher:

DOWNLOAD EBOOK

This volume explores current technologies used to investigate the formation, insertion, and function of metalloclusters associated with proteins. Chapters descr
Binding, Transport and Storage of Metal Ions in Biological Cells
Language: en
Pages: 990
Authors: Wolfgang Maret
Categories: Science
Type: BOOK - Published: 2014-07-09 - Publisher: Royal Society of Chemistry

DOWNLOAD EBOOK

Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others com
Fe-S Cluster Enzymes Part A
Language: en
Pages: 0
Authors:
Categories: Medical
Type: BOOK - Published: 2017-09-01 - Publisher: Academic Press

DOWNLOAD EBOOK

Fe-S Cluster Enzymes, Part A, Volume 595 is the first of two volumes focused on Fe-S cluster enzymes. New topics of note in this series include Electrochemistry