Download or read book Diffuse Large B Cell Lymphoma: Updates on Diagnosis and Treatments written by Robert Ohgami and published by Frontiers Media SA. This book was released on 2024-09-12 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse Large B Cell Lymphoma (DLBCL) is the most common Non-Hodgkin Lymphoma in Western countries and is comprised of a heterogeneous group of biologically distinct entities resulting in the clonal proliferation of a germinal or post-germinal malignant B cell. The disease is particularly aggressive with 40% of the afflicted individuals succumbing to the disease. The standard treatment for DLBCL is still chemo-immunotherapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Whilst this modality is safe and effective, up to 45%–50% of patients will relapse. Despite advances in therapy, DLBCL remains a challenging disease to manage, with significant heterogeneity in clinical presentation and outcomes. Therefore, there is a need to update the medical community with the latest updates in the diagnosis and treatment of DLBCL.