Download or read book Alcohol, Obesity, and Estrogen Regulate Mammary Tumorigenesis Through Adiposity and the PI3K/Akt Signaling Pathway written by Jina Hong and published by . This book was released on 2010 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the most common cancer and the second leading cause of cancer deaths among women in the United States. Alcohol consumption increases breast cancer risk in women. It is unclear whether the effects of alcohol on mammary tumorigenesis are modified by body weight or exogenous estrogen. To determine if the effects of alcohol on mammary tumors are modified by body weight, mice of different body weights (lean, overweight, obese) consuming water or alcohol were injected subcutaneously with mammary cancer cells. To determine if the effects of alcohol on mammary tumors are modified by estrogen, pellets delivering estrogen were implanted into female mice, followed by subcutaneous mammary cancer cell injections. Results show that alcohol-consuming mice were more insulin sensitive and developed larger tumors sooner than water-consuming mice (p