Estrogen Nuclear Receptor Coactivators in Pathogenesis of Breast Cancer
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 1998 |
ISBN-10 | : OCLC:45508701 |
ISBN-13 | : |
Rating | : 4/5 (01 Downloads) |
Download or read book Estrogen Nuclear Receptor Coactivators in Pathogenesis of Breast Cancer written by and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This project focuses on the role of nuclear receptor coactivators in steroid dependent regulation of cell growth in pathogenesis of breast cancer. A novel nuclear receptor coactivator of transcription, p300 and CBP associated factor (p/CAF) has been shown to be required for estrogen, thyroid hormone, and retinoic acid-dependent gene expression. The histone acetyltransferase activity of p/CAF was demonstrated to play essential role in nuclear receptor dependent gene expression and it appeared to be transcription factor specific. The ligand-dependent association of p/CAF with nuclear receptor depends upon nuclear receptor corepressor (NCoR) dismissal. These data suggest that p/CAF complex plays a central role in nuclear receptor dependent gene regulation, a key element in steroid dependent cancer development.